Pyridines and derivatives
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- (867)
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- (1)
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- (1)
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- (54)
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- (1)
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- (1)
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- (6)
- (7)
- (12)
- (1)
- (1)
- (39)
- (1)
- (12)
- (11)
- (4)
- (2)
- (2)
- (15)
- (15)
- (1)
- (1)
- (1)
- (2)
- (9)
- (3)
- (2)
- (1)
- (1)
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- (1)
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- (1)
- (1)
- (1)
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- (3)
- (1)
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- (1)
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- (1)
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- (22)
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Filtered Search Results
Cayman Chemical DmyoInositol1 2 3 5 6pentapho
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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A member of the inositol phosphate family of small, soluble second messengers
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC G-CSF Rat HEK293 2ug
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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G-CSF protein (rat) expressed in HEK293 cells is a glycosylated recombinant cytokine that stimulates granulopoiesis, supports innate immune responses, and promotes differentiation of neural progenitor cells. The lyophilized material is supplied for in vitro biological assays and activity testing, with documented high specific activity and low endotoxin suitable for cell-based experiments.
- Recombinant rat G-CSF produced in HEK293 cells.
- Glycosylated protein with observed molecular weight ~27-32 kDa.
- Stimulates granulopoiesis and supports innate immunity.
- Promotes differentiation of neural progenitor cells.
- High biological potency (ED50 ≤ 16.25 pg/mL; specific activity ≥ 6.15 x 10^7 U/mg).
- Low endotoxin level (<1 EU/μg) for cell-based assays.
- Lyophilized formulation; store frozen and use aliquots after reconstitution.
- Reconstitute at ≥100 μg/mL in ddH2O for recommended handling.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC HP590 | 2971855-37-3 | C29H24F6N4O3 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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HP590 is a novel, potent, and orally active STAT3 inhibitor. It demonstrates anti-proliferative activity in gastric cancer cells and induces apoptosis, inhibiting STAT3 luciferase activity with an IC50 of 27.8 nM and ATP inhibition with an IC50 of 24.7 nM.
- Exhibits anti-proliferative activities against gastric cancer cells such as MKN45, AGS, and MGC803.
- Induces apoptosis in gastric cancer cells.
- Inhibits STAT3 Tyr705 and Ser727 phosphorylation in gastric cancer cells.
- Blocks the expression of STAT3 downstream genes like c-Myc and cyclin D1.
- Reduces IL-6-mediated STAT3 nuclear translocation.
- Inhibits gastric cancer growth in BALB/c-nude mice xenograft models.
- Shows better tolerance in xenograft models, with no weight loss or apparent damage to major organs.
- Inhibits the expression of Ki67, a proliferation marker.
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Medchemexpress LLC Beta-rubromycin | 27267-70-5 | 97.7% | 1 MG
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β-Rubromycin is a quinone-class natural product used as a research reagent with reported telomerase and HIV reverse transcriptase inhibitory activity. It is supplied as a solid for in vitro biochemical assays; consult the product data sheet and SDS for handling, storage, and safety information.
- Quinone antibiotic scaffold with telomerase and reverse transcriptase inhibition.
- High purity research material (97.7%).
- Formula C27H20O12; molecular weight 536.44 g/mol.
- Supplied as a 1 mg solid, soluble in DMSO for in vitro assays.
- For research use only; not for human or clinical use.
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Medchemexpress LLC 1,3-bis(4-aminophenyl)urea | 4550-72-5 | MFCD00797928 | 99.7% | 242.28 g·mol⁻1 | C13H14N4O | 5 MG
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NSC 15364 is a small-molecule inhibitor of VDAC1 oligomerization that suppresses apoptosis in in vitro studies. It is supplied for research use only and is characterized by the molecular formula C13H14N4O and a molecular weight of 242.28 g·mol⁻1. The compound is soluble in DMSO and is offered in powder and solution formats with recommended storage conditions.
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Medchemexpress LLC (±)-CPSI-1306 | 1309793-47-2 | 99.64% | 310.30 | 25 MG
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(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF). It is for research use only.
- Orally available MIF antagonist.
- Shows a significant drop in blood glucose levels and a reduction in serum levels of inflammatory cytokines in mice.
- Effective in treating non-insulin-dependent diabetes mellitus in mice.
- Induces keratinocyte apoptosis as early as 30 minutes after single UVB exposure.
- Reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation.
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Apexbio Technology LLC SKI II 312636-16-1 100mg
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SKI II (CAS 312636-16-1) is a small-molecule inhibitor of sphingosine kinase (SK) an enzyme involved in converting sphingosine into sphingosine-1-phosphate (S1P) SKI II inhibits SK activity with an IC50 of 0 5 M through a mechanism independent of competition at the ATP-binding site Selectivity assessments showed no inhibitory effect against human kinases ERK2 PKC-I or PI3K Cellular assays demonstrate that SKI II effectively inhibits endogenous SK reducing S1P synthesis and subsequently suppressing proliferation and inducing apoptosis in various cancer cell lines including MDA-MB-231 T-24 MCF-7 and MCF-7/VP cells
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Cambridge Isotope Laboratories Diazinon (unlabeled) 1000 ug/mL in nonane 1 2 mL
Diazinon (unlabeled) 1000 ug/mL in nonane 1 2 mL
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Medchemexpress LLC AL 8697 | 1057394-06-5 | 99.8% | 402.41 | 25 MG
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AL 8697 is a specific and orally active p38α MAPK inhibitor with an IC50 of 6 nM. It exhibits 14-fold greater inhibition of p38α compared to p38β (IC50=82 nM) and demonstrates 300-fold selectivity for p38α over a panel of 91 kinases. This compound also possesses anti-inflammatory activity and is for research use only, not for sale to patients.
- Specific and orally active p38α MAPK inhibitor
- High selectivity for p38α over p38β and other kinases
- Anti-inflammatory activity
- For research use only
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Medchemexpress LLC o-3M3FBS | 313981-55-4 | 343.36 | 25 MG
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o-3M3FBS is the negative control of m-3M3FBS. It inhibits inward and outward currents through mechanisms independent of PLC, acting antagonistically. Additionally, o-3M3FBS can increase [Ca2+]i agonistically. In a study, o-3M3FBS (10 μM) decreased AUC from 1058±189 g/min in control (with TTX) to 840±134 g/min, and a higher concentration (25 μM) further reduced AUC to 457±59 g/min.
- Negative control of m-3M3FBS.
- Inhibits inward and outward currents via PLC-independent mechanisms.
- Acts antagonistically.
- Increases [Ca2+]i agonistically.
- Suitable for research on calcium channel activity and neuronal signaling.
- Soluble in various solvents for in vitro and in vivo studies.
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Medchemexpress LLC Relebactam Standard | 5MG
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Relebactam Standard | 5MG
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Apexbio Technology LLC GDC-0032 1282512-48-4 25mg
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GDC-0032 (CAS 1282512-48-4) is a benzofused small-molecule inhibitor targeting PI3K with high potency and selectivity It demonstrates strong inhibitory activity against PI3K PI3K and PI3K with IC50 values of 0 29 nM 0 91 nM and 0 97 nM respectively and notably exhibits greater selectivity towards PI3K In vitro GDC-0032 effectively inhibits cell proliferation and cellular function showing EC50 values of 25 nM (MCF7 cells) and 571 nM (PC3 cells) with corresponding IC50 values of 4 nM and 31 nM In vivo experiments indicate antitumor activity in MCF7-neo/Her2 xenograft models GDC-0032 serves as a valuable tool compound for PI3K-related oncology research
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Medchemexpress LLC Voxilaprevir | 1535212-07-7 | 99.9% | 868.93 | 25 MG
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Voxilaprevir is a noncovalent, reversible inhibitor of HCV NS3/4A protease with pangenotypic antiviral activity. It inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively. It is an orally active direct-acting antiviral agent (DAA) and can be used for HCV infection research.
- Noncovalent, reversible inhibitor of HCV NS3/4A protease.
- Pangenotypic antiviral activity.
- Inhibits genotype 1b and 3a wild-type NS3 proteases with Ki values of 0.038 nM and 0.066 nM, respectively.
- Orally active direct-acting antiviral agent (DAA).
- Used for HCV infection research.
- Solid appearance.
- White to off-white color.
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Medchemexpress LLC Glycoursodeoxycholic acid | 64480-66-6 | 449.62 | 5 MG
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Glycoursodeoxycholic acid, also known as GUDCA, is an acyl glycine and a bile acid-glycine conjugate. It is a metabolite of ursodeoxycholic acid and is intended for research use only. This antioxidant compound has shown therapeutic efficacy in neurodegenerative models and diseases by preventing oxidative stress, metabolic alterations, and cell demise.
- Fully abrogates unconjugated bilirubin (UCB)-induced cytochrome c oxidase inhibition.
- Significantly prevents oxidative stress, metabolic alterations, and cell demise.
- Reduces cytosolic SOD1 inclusions, decreasing mitochondria viability, caspase-9 activation, and apoptosis.
- Demonstrates preventive and restorative effects against UCB-induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells.
- Used for research purposes.
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Medchemexpress LLC Edelfosine | 77286-66-9 | MFCD00135190 | 99.9% | 523.73 g·mol⁻¹ | C27H58NO6P | 5 MG
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Edelfosine ((R)-ET-18-OCH3) is an ether lipid analog used in research for its antiviral and antineoplastic properties. Supplied for laboratory research use only, it is provided as a high-purity reagent for in vitro studies of apoptosis, lipid-mediated signaling, and related biochemical assays.
- High purity (99.9%) for reliable experimental results.
- Ether lipid analog with demonstrated anti-HIV and antineoplastic activity.
- Molecular weight 523.73 g·mol⁻¹ and chemical formula C27H58NO6P for reference.
- Available in small mg-scale pack sizes suitable for laboratory research.
- Datasheet and safety data sheet available to support handling and storage.
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